All Witcher 3 Best Mutations (Ranked From Worst To Best)

Updated:

30 Sep 2022

The Witcher 3: Wild Hunt is an RPG where the possibilities are seemingly endless. The world is vast, the species of monsters are limitless, and you can enhance your character, Geralt, in a number of strategic ways. From weapons, armor, and decoctions, to bombs, signs, and mutations, a player can craft Geralt into the most powerful being alive. Today, we’ll discuss the different mutations a player can craft in the game and rank them from the worst (as in, the least useful in combat) to the best.

12. Toxic Blood

Though Toxic Blood is not as great as the other mutations listed ahead, it’s still a great starter mutation that will come to your aid during battle. Each time a player is struck during combat, their foe will suffer 1.5% the amount of damage for every level of toxicity Geralt has. Geralt’s toxicity reaches a maximum of 150%, so a player has the ability to deal a significant amount of damage to their foe.

Toxic Blood details:

Alchemy Mutation
Deal +1.5% damage for every toxicity point
Requires 2 Ability Points and 2 Greater Green Mutagens

Toxic Blood Usefulness Score: 25/100

11. Deadly Counter

Next we have Deadly Counter, a powerhouse of a mutation that allows the player’s swords to inflict 25% more damage to humans resistant to counterattacks and monsters. Not only that, if your enemy’s vitality is below 25%, Geralt's counterattack will immediately activate a finisher, leaving your foe dead with you coming out victorious.

Deadly Counter details:

Combat mutation
Deal +25% damage to humans resistant to counterattacks and monsters
Trigger finisher if enemy’s vitality is below 25%
Requires 2 Ability Points and 2 Greater Red Mutagens

Deadly Counter Usefulness Score: 35/100

10. Magic Sensibilities

If you love using signs during combat, then the Magic Sensibilities mutation is for you. This mutation allows signs to deal critical hits to opponents, a huge perk when dealing with the more difficult foes. Opponents also have a greater chance of exploding - yes, literally exploding - when struck with one of these critical sign hits. Exploding gets the job done quicker, I suppose.

Magic Sensibilities details:

Sign Mutation
Damage from critical hit intensifies based on player’s level
Requires 2 Ability Points and 2 Greater Blue Mutagens

Magic Sensibilities Usefulness Score: 35/100

9. Euphoria

Not only is this mutation known as Euphoria, it personifies the word as you efficiently slay your enemies with the perks it gives you. This mutation makes each point of toxicity increase the damage from swords and signs by 0.75%. While this may not seem like much, you can combine this mutation with other toxicity-increasing skills and decoctions, and you will slay your enemies with an efficiency you’ve never seen before.

Euphoria details:

Alchemy Mutation
+0.75% damage from swords and signs based on each toxicity point
Requires Toxic Blood, 3 Ability Point, 3 Greater Green Mutagens

Euphoria Usefulness Score: 40/100

8. Mutated Skin

After unlocking Euphoria, you now have access to Mutated skin. Mutated Skin is essentially stronger armor, as it decreases the damage you receive by 15% for each adrenaline point you have. This mutation is key for outlasting those enemies that just won’t die no matter how long you battle them.

Mutated Skin details:

Alchemy Combat Mutation
-15% damage you receive for every adrenaline point you gain
Requires Euphoria, 5 Ability Points, 3 Greater Green Mutagens, 2 Greater Red Mutagens

Mutated Skin Usefulness Score: 40/100

7. Bloodbath

The name speaks for itself. The Bloodbath mutation focuses on dismemberment and fatal blows. When a fatal blow is dealt, your foe is swiftly dismembered and will retainl maximum damage for a quicker kill. Every blow dealt with the Bloodbath mutation increases attack power by 5% until the end of your battle, maxing out at a whopping 250%.

Bloodbath details:

Combat Mutation
Each blow dealt by a weapon in battle increases attack power by 5% until combat ends
Requires Deadly Counter, 3 ability points, 3 Greater Red Mutagens

Bloodbath Usefulness Score: 50/100

6. Cat Eyes

As lethal as a bloodthirsty feline, the Cat Eyes mutation will revolutionize your crossbow game. This mutation increases crossbow damage from 107 to 992 depending on what crossbow you’re using. Your critical hit chances are also raised by 50% and any opponent hit with your arrow who has full health will lose 15% of their vitality.

Cat Eyes details:

Alchemy combat mutation
Crossbow damage increased from 107 to 992
Crossbow critical hit chance increased by 50%
Opponents struck when they have full Vitality lose 15% of Vitality\
Requires Bloodbath and Euphoria, 5 ability points, 3 Greater Green Mutagens, 2 Greater Red Mutagens

Cat Eyes Usefulness Score: 60/100

5. Piercing Cold

Piercing Cold is perfect for the avid users of Aard. When struck with Aard, opponents have a 25% increased chance of getting frozen, and if they’re knocked down and frozen simultaneously, they will die immediately, saving you loads of time in combat.

Piercing Cold details:

Sign Mutation
+25% chance to freeze enemies with Aard
Enemies knocked down and frozen die instantly
Requires Magic Sensibilities, 3 ability points, 3 Greater Blue Mutagens

Piercing Cold Usefulness Score: 70/100

4. Adrenaline Rush

This must be how it feels to chew 5 Gum. Perfect for fighting a large group of enemies, Adrenaline Rush increases attack power and sign intensity by 30% per enemy. So when battling a group of 10 enemies, the bonus is 300%, a massive increase in power for quick and efficient kills.

Adrenline Rush details:

Combat Sign Mutation
Increases attack and sign intensite by 30% per enemy
Requires Piercing Cold and Bloodbath, 5 ability points, 3 Greater Blue Mutagens, 2 Greater Red Mutagens

Adrenaline Rush Usefulness Score: 80/100

3. Conductors of Magic

The Conductors of Magic mutation is going to enhance your sign strength tenfold.. When magic is drawn, unique or Witcher sword, its sign damage will increase by 50%. This is a huge perk for any sword with sign damage, as you’ll waste no time slaying your enemies.

Conductors of Magic details:

Combat Sign Mutation
Any sword with sign damage will increase by 50%
Requires Piercing Cold, 5 ability points, 3 Greater Blue Mutagens, 2 Greater Red Mutagens

Conductors of Magic Usefulness Score: 90/100

2. Metamorphosis

This mutation is expensive, but the cost will be worth the perks. When you apply a critical effect you will trigger a random decoction effect on yourself that will last for 120 seconds. You do not have any control over what decoction effect is triggered, but you have the ability to stack this perk a total of three times.

Metamorphosis details:

Alchemy Combat Sign Mutation
Critical effect triggers random 120 second decoction effect
Requires Cat Eyes, 7 ability points, 3 Greater Green Mutagens, 2 Greater Red Mutagens, 2 Greater Blue Mutagens

Metamorphosis Usefulness Score: 95/100

1. Second Life

Last but certainly not least, we have Second Life. Second Life will be your saving grace when your vitality is low and your difficult enemy is almost dead. The moment you’re completely depleted of vitality, a mutation is triggered that gives you invincibility while your health regenerates to 100%. Though it has a cooldown of 180 seconds, this mutation is great for those tougher enemies.

Second Life details:

Alchemy Combat Mutation
0% vitality triggered invincibility mutation that restores vitality to 100%
Adrenaline Rush, 7 ability points, 2 Greater Blue Mutagens, 3 Greater Red Mutagens, 2 Greater Green Mutagens

Second Life Usefulness Score: 100/100